Tadalafil 20mg (Cialis): Cost, Alternatives, Daily Dose

Tadalafil 20mg is the only oral drug against erectile dysfunction whose effects last for 36 hours. Cialis is the most popular drug against sexual impotence thanks to its high efficacy, heavy-duty action, and simplicity in use – now cheaper as a generic tadalafil tablet.

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Definition and Cost of Tadalafil

Generic Cialis was approved for the use in erectile dysfunction in 2003. This molecule has been an immense marketing success, first under the brand name of Cialis, and then as an independent generic produced by non-developer companies in Europe, U.S. and India.

Cialis restores full ability to achieve hard erections and maintain them for as long as it is optimal for the patient and his partner. The drug is used both on demand and, in lower doses, on daily basis. Its action ranges from immediate erectile aid to long-term recovery from erectile disability. Tadalafil prices went down for the brand drug after the competitively priced generic appeared, but not significantly. Generic product continues to be the most economical way to buy tadalafil.

Cialis properties are unique as compared to those of other drug in its class: its absorption is faster, the half-life and the health effects are much longer (36 hours), and the side effects do not include cyanopsia (“blue vision”).

Effects and benefits

Cialis is the preferred drug among men and their partners, unsurprisingly – because the drug lasts for 36 hours. During its therapeutic window, a man can have multiple erections and powerful ejaculations, enjoy minimal time between sexual acts, and count on flawless hardness of your erections.

Mechanism of action

Cialis dilates the blood vessels in the smooth muscles of the corpora cavernosa of the penis by blocking the enzyme phosphodiesterase type 5 (PDE5). This gives the name to the group of drugs Cialis belongs to: PDE5 inhibitors. PDE5 inhibition regulates the levels of cyclic guanosine monophosphate (cGMP), which in its turn stabilizes nitric oxide (NO) at the optimal levels. NO is the essential substance promoting blood absorption and retention in the penis that results in erection. This chain of chemical reactions ensures that patient can achieve exceptional erectile hardness with minimal sexual stimulation.

How to dose and use Tadalafil Generic

The right dose of Cialis should be determined by the doctor; generic Cialis is available in doses 2.5 mg, 5 mg, 10 mg, and 20 mg. The go-to dose is 10 mg, which can be upped to 20 mg if you are not happy with the results. See in more detail in the table below:

Dosage Indications Benefits Purpose
Tadalafil 2.5 mg Daily use Minimal side effects Consistent recovery Safe for use in older and comorbid patients Erectile dysfunction treatment Benign prostate hyperplasia treatment
Tadalafil 5 mg Daily use Minimal side effects Consistent recovery Safe for use in older and comorbid patients Erectile dysfunction treatment Benign prostate hyperplasia treatment
Tadalafil 10 mg On-demand use Low side effect profile Optima correlation between efficacy and safety Mild erectile dysfunction treatment
Tadalafil 20 mg On-demand use Efficacy in complicated cases of erectile dysfunction Moderate to severe Erectile dysfunction treatment

How do I use Tadalafil?

Cialis is used on demand. Take 1 tablet 30-60 minutes before its effects are needed. Do not take the next dose of Cialis during the following 24 hours. Cialis can be taken with or without meals; taking the drug after a meal minimizes tadalafil side effects. Can I take Cialis with alcohol? It is not recommended to take Cialis with more than 1-3 units of alcohol, because both tadalafil and ethanol lower the blood pressure, and their combination can cause a sudden and dangerous hypotensive episode. Do not use Cialis in the presence of the diseases of heart, kidneys, liver, stomach, some eye diseases, low blood pressure and penile deformity. Discuss with your doctor if you can safely engage in sexual activity in case physical strain is contraindicated to you. Give your prescriber a full list of currently used drugs.

Oral Tadalafil Shows Great Effectiveness for Men with ED and Comorbid Diabetes

Erectile dysfunction (ED) is a widespread male sexual health problem often found in patients diagnosed with type 2 diabetes. Modern medicine attributes this to the damage that poorly managed diabetes inflicts on the nerves, including those that control sexual stimulation and are responsible for triggering an erection. One more contributing factor here is the decreased blood flow resulting from injured small blood vessels.

Fortunately, patients whose ED is linked to diabetes have a variety of treatment options available to them. Some recent studies have shown that 10mg or 20mg tadalafil, the central active drug substance in Cialis, can effectively reduce the symptoms of erectile dysfunction in diabetic men and facilitate erections on demand. It has also been concluded that continuous treatment with smaller daily doses of 2.5mg and 5mg tadalafil can significantly improve the patient’s long-term ability to engage in penetrative sex and achieve is satisfactory completion without much preparation and waiting. 

In all, tadalafil is a safe and well-tolerated oral ED medication with a proven success record of helping men diagnosed with diabetes improve their sex life. Taken daily or as needed, tadalafil can reduce symptoms of erectile dysfunction and enhance men’s ability to respond to sexual stimulation, producing an erection that is hard enough to let them engage in satisfactory intercourse.

Cautious

Cialis dose needs to be revised in men with compromised function of liver or kidneys. As a rule, older age (65 and upwards) is not a reason to decrease the dose to the minimal, but in presence of comorbidities your doctor may appoint a lower dose of Cialis. You should also keep in mind the following safety rules:

  • Do not drive, use machinery, or do anything that requires mental alertness until it is safe to do so.
  • Limit your consumption of alcoholic beverages.
  • Call your doctor immediately if you experience: dizziness or nausea during sexual activity, or if you experience pain, numbness, tingling in the chest, arms, neck or jaw.

Contraindicative conditions

The following groups of patients cannot take Cialis with guaranteed safety:

  • Men with heart disease or stroke in the medical history of the past 6 months;
  • Men with renal impairment;
  • Men with hepatic dysfunction;
  • Men with leukemia, sickle cell disease, myeloma;
  • Men with retinitis pigmentosa, naion, or angular glaucoma;
  • Men with ulcer of stomach or duodenum;
  • Men with Peyronie’s disease or priapism.

Cialis with other medications

Give your prescriber a full list of currently used pharmaceuticals. Cialis is incompatible with the following medications:

  • nitrate-based drugs lowering blood pressure;
  • drugs managing AIDS or HIV;
  • drugs against mycosis;
  • some antibiotics;
  • MAO inhibitors (certain antidepressives);
  • other PDE5 inhibitors.

Side effects of Tadalafil

Cialis side effects are not intense or bothersome; not everyone will experience them. In the table below, we cite the most common adverse reactions to tadalafil, alongside with quick mitigating solutions:

  Side Effect Frequency (C = Common, R = Rare,  ER = Extremely Rare)   How To Minimize
Muscle pain C   To minimize the side effects of Cialis, the following steps can be taken:

  • Take Cialis on a full stomach
  • Increase your water intake
  • Discuss dose adjustment with your doctor
  • Follow the dosing instructions
  • Do not use with alcohol
Rhinitis C
Sinusitis C
Skin rash R
Stomach upset C
Diarrhea C
Nausea C
Headache C
Vision disturbance R
Flushing C
Chest pain ER   Important! These severe side effects require immediate medical attention and discontinuation of the drug’s use.
Arm pain ER
Swelling of face ER
Palpitations ER
Difficulty breathing ER
Painful erection ER

Overdose

Do not take more than one recommended dose of Cialis per day. If you are not happy with the effects your current dose offers, do not self-administer a higher dose. You should talk to your doctor and discuss the increase in Cialis amount recommended for single intake. Your doctor may also consider other erectile dysfunction medications like sildenafil or vardenafil that work in non-responders to Cialis. If you suspect that you have taken an elevated dose of Cialis, seek medical help. Toxicity of Cialis can manifest itself as severe headache, lightheadedness, irregular heartbeat, prolonged or painful erection.

Storage

Store Cialis in a place where it cannot be reached by minors or pets, at a room temperature away from heat and humidity. Dispose of pills after the expiry date; consult your pharmacist on how to do it in an environmentally-friendly way.

Toxicity

Doses of Cialis that exceed those recommended for the use during 24 hours are considered toxic and can lead to overdose symptoms. Medical help will be required for managing the adverse reactions linked to Cialis toxicity.

Tolerance

Generic Cialis efficacy does not diminish with continuous use. On the contrary, it has an accumulative effect, and after a course of 12 weeks of daily Cialis use some patients can achieve erection without pharmaceutical support. In case you develop psychological dependence on erectile dysfunction drugs, talk to a therapist.

Generics vs. brand drugs: should I pay more?

Generic Cialis contains the same active substance as the brand drug, which makes them a) identical and b) interchangeable. Your doctor will prescribe tadalafil to you, and you can choose between the brand and the generic version based on your budget. There is no difference in efficacy or safety; the cost of generic drugs does not reflect their subpar quality, but it conditioned by the marketing laws. Generic drug manufacturers do not have to invest into developing the formula, therefore these investments are not included in the cost of their products. You can order generic Cialis online without prescription.


Disclaimer: The information you can find in this article is presented purely for educational purposes. Any drugs and their exact dosages should be selected only after consulting a medical professional that is aware of your medical history. The article doesn’t offer in-depth information regarding Tadalafil Citrate so it shouldn’t be used as a guideline in your treatment. Taking this drug without consulting a specialist can be dangerous and increase the risk of side effects. If you are interested in taking this medication, you may need to undergo a physical examination and perform laboratory tests to assess your current state of health. This site doesn’t bear responsibility for the information presented here and any instances that may arise from following these recommendations.