Piroxicam (Feldene): Anti-inflammatory Drug (NSAID)

  • Type of Drug: Nonsteroidal anti-inflammatory drug (NSAID).
  • Prescribed for: Rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, menstrual pain, and sunburn treatment.

General Information of Piroxicam

Piroxicam is one of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation. We do not know exactly how NSAIDs work, but part of their action may be due to an ability to inhibit the body’s production of a hormone called prostaglandin and to inhibit the action of other body chemicals, including cyclo-oxygenase, lipoxygenase, leukotrienes, lysosomal enzymes, and a host of other factors. NSAIDs are generally absorbed into the bloodstream fairly quickly. Pain relief comes within an hour after taking the first dose of Piroxicam and lasts for 2 to 3 days, but its anti-inflammatory effect takes a lot longer (several days to 2 weeks) to become apparent, and may take 3 weeks to reach its maximum effect. Piroxicam is broken down in the liver and eliminated through the kidneys.

Feldene Cautions and Warnings

People who are allergic to Piroxicam (or any other NS AID) and those with a history of asthma attacks brought on by an NSAID, Iodides, or Aspirin should not take Piroxicam. Piroxicam can cause gastrointestinal (GI) bleeding, ulcers, and stomach perforation. This can occur at any time, with or without warning, in people who take chronic Piroxicam treatment. People with a history of active GI bleeding should be cautious about taking any NSAID. Minor stomach upset, distress, or gas is common during the first few days of treatment with Piroxicam. People who develop bleeding or ulcers and continue treatment should be aware of the possibility of developing more serious drug toxicity. Piroxicam can affect platelets and blood clotting at high doses, and should be avoided by people with clotting problems and by those taking Warfarin. People with heart problems who use Piroxicam may experience swelling in their arms, legs, or feet. Piroxicam can cause severe toxic effects to the kidney. Report any unusual side effects to your doctor, who may need to test your kidney function periodically. Piroxicam can make you unusually sensitive to the effects of the sun (photosensitivity).

Possible Side Effects

  • Most common: diarrhea, nausea, vomiting, constipation, stomach gas, stomach upset or irritation, and loss of appetite.
  • Less common: stomach ulcers, GI bleeding, hepatitis, gallbladder attacks, painful urination, poor kidney function, kidney inflammation, blood and protein in the urine, dizziness, fainting, nervousness, depression, hallucinations, confusion, disorientation, tingling in the hands or feet, light-headedness, itching, increased sweating, dry nose and mouth, heart palpitations, chest pain, difficulty breathing, and, muscle cramps.
  • Rare: severe allergic reactions, including closing of the throat, fever and chills, changes in liver function, jaundice (yellowing of the skin or eyes), and kidney failure. People who experience such effects must be promptly treated in a hospital emergency room or doctor’s office. NSAIDs have caused severe skin reactions; if this happens to you, see your doctor immediately.

Drug Interactions of Feldene

  • Piroxicam can increase the effects of oral anticoagulant (blood-thinning) drugs such as Warfarin. You may take this combination, but your doctor may have to reduce your anticoagulant dose.
  • Taking Piroxicam with Cyclosporine may increase the toxic kidney effects of both drugs. Methotrexate toxicity may be increased in people also taking Piroxicam.
  • Piroxicam may reduce the blood-pressure-lowering effect of beta blockers and loop diuretic drugs.
  • Piroxicam may increase blood levels of Phenytoin, leading to increased Phenytoin side effects. Blood-Lithium levels may be increased in people taking Piroxicam.
  • Piroxicam blood levels may be affected by Cimetidine because of that drug’s effect on the liver.
  • Probenecid may interfere with the elimination of Piroxicam from the body, increasing the chances for Piroxicam toxic reactions.
  • Aspirin and other salicylates may decrease the amount of Piroxicam in your blood. These medicines should never be taken at the same time.

Food Interactions

Take Piroxicam with food or a magnesium/aluminum antacid if it upsets your stomach.

Feldene Usual Dose

  • Adult: 20 mg per day. Take each dose with a full glass of water and don’t lie down for 15 to 30 minutes after you take the medicine.
  • Child: not recommended.


People have died from NSAID overdoses. The most common signs of overdosage are drowsiness, nausea, vomiting, diarrhea, abdominal pain, rapid breathing, rapid heartbeat, increased sweating, ringing or buzzing in the ears, confusion, disorientation, stupor, and coma. Take the victim to a hospital emergency room at once. ALWAYS bring the medicine bottle.

Special Information of Piroxicam

Check with your pharmacist if you are unsure about whether you may or may not crush or chew Piroxicam. Piroxicam can make you drowsy and/or tired: Be careful when driving or operating hazardous equipment. Do not take any nonprescription products with Acetaminophen or Aspirin while taking this drug; also, avoid alcoholic beverages. Contact your doctor if you develop skin rash or itching, visual disturbances, weight gain, breathing difficulty, fluid retention, hallucinations, black or tarry stools, persistent headache, or any unusual or intolerable side effects. If you forget to take a dose of Piroxicam take it as soon as you remember. If you take it once a day and it is within 8 hours of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

Special Populations

Pregnancy/Breast-feeding NSAIDs may cross into the fetal blood circulation. They have not been found to cause birth defects, but may affect a developing fetal heart during the second half of pregnancy; animal studies indicate a possible effect. Women who are or who might become pregnant should not take Piroxicam without their doctors’ approval; be particularly cautious about using this drug during the last 3 months of your pregnancy. When the drug is considered essential by your doctor, its potential benefits must be carefully weighed against its risks. NSAIDs may pass into breast milk, but have caused no problems among breast-fed infants, except for seizures in a baby whose mother was taking Indomethacin. Other NSAIDs have caused problems in animal studies. There is a possibility that a nursing mother taking Piroxicam could affect her baby’s heart or cardiovascular system. If you must take Piroxicam, bottle-feed your baby. Seniors Older adults may be more susceptible to Piroxicam side effects, especially ulcer disease.

Disclaimer: The information you can find in this article is presented purely for educational purposes. Any drugs and their exact dosages should be selected only after consulting a medical professional that is aware of your medical history. The article doesn’t offer in-depth information regarding Feldene so it shouldn’t be used as a guideline in your treatment. Taking this drug without consulting a specialist can be dangerous and increase the risk of side effects. If you are interested in taking this medication, you may need to undergo a physical examination and perform laboratory tests to assess your current state of health. This site doesn’t bear responsibility for the information presented here and any instances that may arise from following these recommendations.